Recovery & Performance

CJC-1295

Modified GRF (1-29), No DAC

There are two versions of CJC-1295 in circulation, and the difference matters more than most people realize. The DAC version carries a drug affinity complex that extends its half-life to roughly a week, producing a sustained elevation in growth hormone. The No DAC version — also called Modified GRF (1-29), and the one we use — clears in about half an hour. That short window is deliberate. It means the peptide amplifies the body’s own growth hormone pulses rather than overriding the pulsatile rhythm the body uses to regulate itself. It is the same compound inside Vitality Surge and Pure Renew Essence, now available on its own.

Benefits

Supports natural growth hormone release while preserving the body’s own pulsatile rhythm.

No DAC formulation preserves natural growth hormone pulsatility
Supports recovery, sleep quality, and lean body composition
Complements ghrelin-receptor peptides such as Ipamorelin
Short half-life allows precise timing around the body’s evening release window
Available standalone or inside Vitality Surge and Pure Renew Essence

Safety Information

Generally well tolerated. Lightheadedness, flushing, or warmth at the injection site may occur shortly after administration. Not recommended during pregnancy, while breastfeeding, or with a history of active cancer. Patients with impaired glucose tolerance should be monitored by their provider. Always consult your provider before starting.

Regimen

6 or 12 weeks of injections Monday through Friday in the afternoon or evening. Dosing guide: 5 days on, 2 days off. Evening administration aligns dosing with the body’s largest natural growth hormone release window.

How to Take

Subcutaneous injection near the lower abdomen or outer thigh. Use sterile technique. Rotate injection sites.

How It Works

CJC-1295 is a 29-amino-acid analog of growth hormone-releasing hormone, modified at four positions to resist enzymatic breakdown. It binds GHRH receptors on the anterior pituitary and signals growth hormone release. Without the drug affinity complex, its half-life is roughly thirty minutes — long enough to meaningfully amplify a natural pulse, short enough that the pituitary returns to baseline between doses. That rhythm matters, because sustained growth hormone elevation is associated with receptor downregulation over time, while pulsatile signaling is the pattern the body uses natively.

CJC-1295 No DAC — Modified GRF (1-29) — is a stabilized version of the first 29 amino acids of growth hormone-releasing hormone, the same fragment that sermorelin is based on. The four amino acid substitutions were introduced to resist the enzyme that breaks GHRH down within minutes, extending activity to roughly half an hour. That is the design intent: long enough to amplify a natural pulse, short enough to preserve the pulsatile rhythm. The DAC version, by contrast, was engineered for a week-long half-life and produces a sustained elevation, which is a different physiological profile and the reason we do not use it. Human data on the No DAC form specifically is limited; most of the human research on GHRH 1-29 analogs comes from sermorelin, which shares the core structure. Compounded CJC-1295 is not an FDA-approved product.

FAQs

What is the difference between CJC-1295 DAC and No DAC?

DAC (drug affinity complex) extends the half-life to about a week and produces a sustained growth hormone elevation. No DAC clears in about 30 minutes and amplifies the body’s natural pulses instead. Pure Hydration uses No DAC because pulsatile signaling is how the body regulates growth hormone natively.

Is CJC-1295 No DAC the same as sermorelin?

Closely related. Both are based on the first 29 amino acids of GHRH. CJC-1295 No DAC has four substitutions that make it more resistant to breakdown, so it produces a stronger pulse from the same mechanism.

Why is CJC-1295 paired with ipamorelin?

They act on different pituitary receptors — GHRH and ghrelin. Stimulating both at once produces a larger growth hormone release than either alone. That pairing is Vitality Surge.

When should I take CJC-1295?

Evening, Monday through Friday, 5 days on and 2 days off, for 6 or 12 weeks. The body’s largest natural growth hormone pulse occurs in the first hours of sleep, so evening dosing aligns with it.

Who should not use CJC-1295?

Anyone pregnant or breastfeeding, or with a history of active cancer. Patients with impaired glucose tolerance should be monitored, since growth hormone affects insulin sensitivity. Your provider reviews this at consultation.

How to Use Your Peptides

Before you get started with your peptide protocol, we recommend reviewing our Injection Guide to ensure safe and effective use. This quick-reference document walks you through proper subcutaneous injection technique, storage tips, and other best practices.

Each protocol below includes recommended timing, injection instructions, safety notes, and how the peptides work in your body. As always, please follow your provider’s guidance, and please reach out with any questions!