Cognitive & Energy Enhancement

NAD+

NAD+ is a coenzyme your body produces naturally — but levels drop significantly with age, stress, and metabolic demand. Whether you’re focused on energy, mental clarity, recovery, or long-term cellular health, NAD+ is one of the most studied and clinically recognized tools in the longevity space.

Benefits

NAD+ therapy is sought by patients dealing with a wide range of concerns — and the common thread is usually that they want their body running better at a foundational level. NAD+ is involved in how your cells produce energy, how your brain maintains focus and clarity, and how your body manages the daily wear of physical and metabolic stress. Patients dealing with persistent fatigue, mental fog, slow recovery, or a general sense that their body isn’t bouncing back the way it used to will often find NAD+ relevant to those patterns. It’s also one of the most well-researched protocols for patients investing in healthy aging and long-term cellular resilience. As with any protocol, the right approach depends on your goals, health history, and clinician guidance.

Safety Information

NAD+ therapy is generally well-tolerated when administered by a qualified clinical team, but there are a few things to know going in. The most common experience during the treatment is a feeling of pressure in the chest, mild nausea, or flushing — these sensations are normal and typically resolve immediately when the drip rate is slowed. Our nurses monitor you throughout and adjust as needed. NAD+ therapy is not appropriate for patients who are pregnant or breastfeeding, or those with active atrial fibrillation. If you have a complex cardiac history or are currently taking prescription medications, let your nurse know before your session — some situations require additional screening through our Medical Director before we proceed. Infection risk is minimal when proper technique is used, which our clinical team follows for every patient.

Regimen

NAD+ is most commonly run as a twice-weekly protocol, with sessions spaced a few days apart to give your body time to integrate between visits. A monthly maintenance option is also available for patients who’ve completed an initial series and want to sustain their results over time. Most patients find that consistency matters more than frequency — showing up regularly on a schedule that works for your life tends to produce better long-term results than cramming sessions. Your provider will help you choose the right starting cadence based on your goals and how your body responds to the first few sessions.

How to Take

NAD+ at Pure Hydration is administered as a subcutaneous injection near the lower abdomen or outer thigh. The process takes under a minute once you’re comfortable with it. Clean, sterile technique is essential every time: wash your hands thoroughly, prep the skin with an alcohol swab, let it dry fully before injecting, and rotate sites to avoid buildup at any single location. Avoid injecting into bruised, irritated, or scarred tissue. Each shipment from Pure Hydration includes your peptide vials, bacteriostatic water, two weeks of sealed needles, a protocol-specific dosing guide, and a full injection guide. If you’re new to self-injection, an instructional video tutorial is also available to walk you through the process step by step.

How It Works

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body, where it plays a central role in the mitochondrial process that converts nutrients into usable energy. It also activates a class of proteins called sirtuins, which are involved in DNA repair, gene expression, and the body’s response to cellular stress — pathways closely tied to how we age at the biological level. The brain relies heavily on NAD+ for neuronal function, which is why mental clarity and focus are among the most commonly reported areas patients notice. Delivery works by bypassing the digestive system entirely, allowing the full dose to reach circulation directly — a meaningful advantage over oral NAD+ precursors, which lose a significant portion of their effect through the absorption process.

How to Use Your Peptides

Before you get started with your peptide protocol, we recommend reviewing our Injection Guide to ensure safe and effective use. This quick-reference document walks you through proper subcutaneous injection technique, storage tips, and other best practices.

Each protocol below includes recommended timing, injection instructions, safety notes, and how the peptides work in your body. As always, please follow your provider’s guidance, and please reach out with any questions!